Adopting a wholesome lifestyle can scale back the danger of dementia in individuals with a household historical past

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Brellenthin A et al. Presentation 74. Presented at: American Heart Association Scientific Sessions on Epidemiology, Prevention, Lifestyle, and Cardiometabolic Health; May 20-21, 2021 (virtual meeting).

Disclosure:
Brellenthin and Elkind do not report any relevant financial information.

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Adopting at least three healthy behaviors was associated with a reduced risk of dementia in those with familial dementia, a spokesman reported.

“When dementia runs in a family, both genetic and non-genetic factors such as eating habits, physical activity, and smoking status affect a person’s overall risk.” Angelique Brellenthin, PhD, Assistant Professor of Kinesiology at Iowa State University said in a press release. “This means that there are ways to reduce the risk by taking these non-genetic factors into account.”

dementia

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The study, presented at the American Heart Association’s scientific sessions on epidemiology, prevention, lifestyle, and cardiometabolic health, enrolled 302,239 people aged 50 to 73 years without baseline dementia. Each participant completed the basic examinations from 2006 to 2010 as part of the British biobank study.

Familial dementia was defined as dementia in a first-degree relative such as a mother, father, or sibling. Participants were divided into groups based on whether they had two or fewer, three, four, five, or six healthy behaviors, including:

  • a BMI of <30 kg / m²;
  • moderate to vigorous physical activity of at least 150 minutes per week;
  • Sleep duration from 6 to 9 hours per day;
  • drink in moderation (> 0 to < 14 drinks per week for men and > 0 to <7 drinks per week for women);
  • do not smoke; and
  • healthy eating with more fruits and vegetables and less processed meat and refined grains.

In the cohort, 0.6% of participants developed dementia during the 8-year follow-up period. People with a family history of dementia had a more than 70% increased risk of dementia compared to people without (HR = 1.72; 95% CI, 1.53-1.93).

After adjusting for confounders, including familial dementia, compared to subjects with two or less healthy behaviors, subjects with three (HR = 0.7; 95% CI, 0.57-0.86), four (HR = 0.58 ; 95% CI, 0.48-0.7) Five (HR = 0.58; 95% CI, 0.48-0.7) or six (HR = 0.49; 95% CI, 0.39- 0.6) healthy behaviors had a reduced risk of dementia.

In the joint analysis, people with familial dementia and two of less healthy behaviors were compared to persons with familial dementia and at least three healthy behaviors (HR = 0.65; 95% CI, 0.42-0.99), persons without familial Dementia and two or less less healthy behaviors (HR = 0.74; 95% CI, 0.47-1.15) and people without familial dementia and at least three healthy behaviors (HR = 0.37; 95% CI, 0, 25-0.56) had a lower risk of dementia.

According to the researchers, participating in at least three healthy lifestyle behaviors can significantly lower the risk of dementia, even in those at higher risk due to familial dementia.

Mitchell SV Elkind

“This study provides important evidence that a healthy lifestyle can have positive effects on brain health.” Mitchell SV Elkind, MD, MS, FAHA, FAAN, The President of the AHA, professor of neurology and epidemiology at Vagelos College for Doctors and Surgeons, and Mailman School of Public Health and attending neurologist at Irving Medical Center, New York Presbyterian / Columbia University, said in the press release. “It should be comforting and inspiring for people to know that following just a few healthy behaviors can delay cognitive decline, prevent dementia, and maintain brain health.”

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Scientific Sessions on AHA EPI / Lifestyle and Cardiometabolic Health

Scientific Sessions on AHA EPI / Lifestyle and Cardiometabolic Health