MONDAY, April 12, 2021 (HealthDay News) – Genetic factors are linked to an increased risk of general and fatal prostate cancer, and following a healthy lifestyle may reduce the risk of fatal diseases in men in the quartile with the highest genetic risk, according to a study , unveiled during week 1 of the American Association for Cancer Research’s annual meeting, held practically April 10-15.
Anna Plym, Ph.D., of Brigham and Women’s Hospital, Boston, and colleagues used a validated polygenic risk score (PRS) for total prostate cancer to estimate the genetic risk for prostate cancer in 10,443 men in the follow-up study for relatives of health professionals to quantify. A validated lifestyle score was used for fatal prostate cancer and the incidence of total and fatal prostate cancer was assessed during the follow-up visit.
During the median follow-up of 18 and 22 years, the researchers identified 2,111 prostate cancer and 238 fatal prostate cancer events. According to the risk stratification with the PRS, men in the quartile with the highest versus the lowest genetic risk had an increased risk of total prostate cancer and fatal prostate cancer (hazard ratios, 5.39 and 3.53, respectively). Adhering to a healthy lifestyle versus the least healthy lifestyle was significantly associated with a reduced risk of fatal prostate cancer in men in the quartile with the highest genetic risk (hazard ratio, 0.54). No association has been found between maintaining a healthy lifestyle and an overall reduced risk of prostate cancer.
“The reduced risk of aggressive disease in people with favorable lifestyles could suggest that the excessive genetic risk of fatal prostate cancer could be offset by following a healthy lifestyle,” Plym said in a statement.